Super Tilosin 50

The Alternative Macrolide Antibiotics

• Has a large lactone ring in their structure.
• More effective against mycoplasma, gram-positive bacteria and some ricketsiae.
• A macrolide antibiotic is a complex mixture of closely related antibiotic compounds, differing in the chemical substitutions.
• Mode of action: binds to the 50 S subunit of ribosomes causing interference in protein synthesis. Bacteriostatic.

Antimicrobial Spectra of Macrolide Antibiotics

• Active against mycoplasma.
• Active against most aerobic and anaerobic gram-positive bacteria. Not active against gram-negative bacteria.

Macrolide Antibiotics: Pharmacokinetics

• Absorption: Readily absorbed from the GI tract. Peak plasma concentration within 1 to 2 hours.
• Distribution: Widely distributed, concentrated in spleen, liver, kidneys and particularly lungs. Accumulate in macrophages at 20X plasma concentration.
• Excretion: Mainly excreted in the bile (60%).
• Half-life: Plasma half-life is 1 to 3 hours.

Macrolide Antibiotics: Interactions

• Toxicity and side effects are uncommon.
• Synergistic with tetracyclines.
• Should not be used with chloramphenicol and lincosamide as they all binds to the 50 S ribosomal site.

The Specialty of Super Tilosin 50

• It is not a copy of tylosin tartrate.
• Made by bio-chemical conversion of tylosin tartrate.
• Claimed to be up to 10 times more effective than tylosin.
• Claimed to control Mycoplasma strains resistant to tylosin.
• Recommended dose is 0.125 g/l
• Economical as this dose is 1/4 that of tylosin.
• Claimed to give better bio-availability and blood levels.
• Has a 5 day withdrawal period.
• Contains Acetyl-isovalery-ltylosin tartrate 5%  as the active ingredient.
• Granular and free flowing.
• Totally soluble in water within 1 minute in low concentration to give a clear solution.
• When dissolving SUPER TILOSIN 50 in water, always add SUPER TILOSIN 50 to the water and not the reverse.

Sensitivity of Mycoplasma gallisepticum isolates to SUPER TILOSIN 50 and TYLOSIN

• All MG isolates tested were sensitive to SUPER TILOSIN 50.
• MG isolates with MIC greater than 0.06 mcg/ml are regarded as resistant to TYLOSIN but sensitive to SUPER TILOSIN 50.

Details of the laboratory MICs studies on M. gallisepticum.

• In a test using equal dose rates, SUPER TILOSIN 50 achieves higher blood levels than Tylosin.
• Data on tissue distribution show that both SUPER TILOSIN 50 and Tylosin concentrate in tissues.

Metabolism of SUPER TILOSIN 50

• SUPER TILOSIN 50 is rapidly metabolised to 3 acetyl tylosin and then excreted
• 60% of SUPER TILOSIN 50 activity excreted in urine is  the 3 acetyl metabolite*
• 93% of activity excreted in faeces is the 3 acetyl metabolite*.

Studies on the anti-mycoplasmal activity of 3 acetyl tylosin indicate that: it is markedly less active compared to SUPER TILOSIN 50 or tylosin

SUPER TILOSIN 50: Safety Test in chickens

• SUPER TILOSIN 50 was tested for safety at 30, 90 and 150 mg/kg body weight for 3 days or with 30 mg/kg body weight for 15 days.
• There were no adverse effects in the chickens.

SUPER TILOSIN 50 has a wide margin of safety and is safe for use at day 1 of age.

SUPER TILOSIN 50: INDICATIONS

• Recommended for the prevention and treatment of mycoplasmosis caused by M. gallisepticum and infectious synovitis caused by M. synoviae in chickens.
• For the prevention and treatment of infection caused by Ornithobacterium rhinotracheale (ORT) in poultry.

For prevention and treatment of enteritis caused by Clostridium perfringens.

Recommended use programs of SUPER TILOSIN 50 in chickens

• Prophylactic use:
• First 3 days after placement: Use SUPER TILOSIN 50 in the drinking water at 25 mg/kg body wt.
• On day 18 to 21, or at time of vaccination stress, use SUPER TILOSIN 50 at the same dosage for 2 consecutive days.
• Therapeutic use:
• At the onset of clinical signs of mycoplasmosis / CRD, use AIVLOSIN in the drinking water at 25 mg/kg body wt. for 3 consequtive days.

(Tests in broilers showed 0.5 g / L in drinking water as the effective dosage. At 0.25 g/L, the efficacy is lowered). 

FOOD SAFETY ASPECT

• Practise safe withdrawal period of 3 days in chickens.

Not recommended for use in egg producing hens meant for human consumption.